The story of Phra Pathom Chedi National Museum began in the reign of King Chulalongkorn when Prince Damrongrajanubhap had set the plan to collect the antiques scattered in Nakhon Pathom. Then, the Nakhon Pathom governor, Chao Phraya Sri Wichaichanin, ordered Luang Buddhakasettranurak and Luang Chaiyaratraksa to implement the plan.
         Initially, the gathered antiques were kept in the veranda of Phra Pathom Chedi. Then in 1911, the collections were shifted to the vihara opposite to the main chapel of the temple which was later called Phra Pathom Chedi Museum. (It is still the temple museum) Later the museum was transferred to be under the Fine Arts Department and became the National Museum in 1934. Due to the limitation of space, in 1967 the existing building was built to house the collection. Mostly, the collection in this museum is evidence of The Dvaravati culture which was the glorious past of Nakhon Pathom.